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Materials
Volume 17
Issue 10
10.3390/ma17102413
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Open AccessArticle
by Gregorio Marchiori SciProfilesScilitPreprints.orgGoogle Scholar Devis Bellucci SciProfilesScilitPreprints.orgGoogle Scholar Alessandro Gambardella SciProfilesScilitPreprints.orgGoogle Scholar Mauro Petretta SciProfilesScilitPreprints.orgGoogle Scholar Matteo Berni SciProfilesScilitPreprints.orgGoogle Scholar Marco Boi SciProfilesScilitPreprints.orgGoogle Scholar Brunella Grigolo SciProfilesScilitPreprints.orgGoogle Scholar Gianluca Giavaresi SciProfilesScilitPreprints.orgGoogle Scholar Nicola Baldini SciProfilesScilitPreprints.orgGoogle Scholar Valeria Cannillo SciProfilesScilitPreprints.orgGoogle Scholar Carola Cavallo SciProfilesScilitPreprints.orgGoogle Scholar
Gregorio Marchiori
, 
Devis BellucciAlessandro Gambardella, Mauro Petretta, Matteo Berni, Marco Boi, Brunella Grigolo, Gianluca Giavaresi, 
Nicola BaldiniValeria Cannillo and Carola Cavallo
1
Scienze e Tecnologie Chirurgiche, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
2
Department of Engineering “Enzo Ferrari”, University of Modena and Reggio Emilia, 41125 Modena, Italy
3
REGENHU SA, 1690 Villaz-St-Pierre, Switzerland
4
Laboratorio di Tecnologia Medica, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
5
Scienze e Tecnologie Biomediche e Nanobiotecnologie, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
6
Laboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
7
Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
These authors contributed equally to this work.
Materials 2024, 17(10), 2413; https://doi.org/10.3390/ma17102413
Submission received: 29 March 2024/Revised: 24 April 2024/Accepted: 9 May 2024/Published: 17 May 2024
Abstract
In the development of bone graft substitutes, a fundamental step is the use of scaffolds with adequate composition and architecture capable of providing support in regenerative processes both on the tissue scale, where adequate resistance to mechanical stress is required, as well as at the cellular level where compliant chemical–physical and mechanical properties can promote cellular activity. In this study, based on a previous optimization study of this group, the potential of a three-dimensional construct based on polycaprolactone (PCL) and a novel biocompatible Mg- and Sr-containing glass named BGMS10 was explored. Fourier-transform infrared spectroscopy and scanning electron microscopy showed the inclusion of BGMS10 in the scaffold structure. Mesenchymal stem cells cultured on both PCL and PCL-BGMS10 showed similar tendencies in terms of osteogenic differentiation; however, no significant differences were found between the two scaffold types. This circ*mstance can be explained via X-ray microtomography and atomic force microscopy analyses, which correlated the spatial distribution of the BGMS10 within the bulk with the elastic properties and topography at the cell scale. In conclusion, our study highlights the importance of multidisciplinary approaches to understand the relationship between design parameters, material properties, and cellular response in polymer composites, which is crucial for the development and design of scaffolds for bone regeneration.
Keywords: PCL; bioactive glasses; therapeutic ions; magnesium; composite scaffolds; human bone-marrow-derived mesenchymal stem cells; tissue engineering; bone
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MDPI and ACS Style
Marchiori, G.; Bellucci, D.; Gambardella, A.; Petretta, M.; Berni, M.; Boi, M.; Grigolo, B.; Giavaresi, G.; Baldini, N.; Cannillo, V.;et al. A Multidisciplinary Evaluation of Three-Dimensional Polycaprolactone Bioactive Glass Scaffolds for Bone Tissue Engineering Purposes. Materials 2024, 17, 2413.https://doi.org/10.3390/ma17102413
AMA Style
Marchiori G, Bellucci D, Gambardella A, Petretta M, Berni M, Boi M, Grigolo B, Giavaresi G, Baldini N, Cannillo V,et al. A Multidisciplinary Evaluation of Three-Dimensional Polycaprolactone Bioactive Glass Scaffolds for Bone Tissue Engineering Purposes. Materials. 2024; 17(10):2413.https://doi.org/10.3390/ma17102413
Chicago/Turabian Style
Marchiori, Gregorio, Devis Bellucci, Alessandro Gambardella, Mauro Petretta, Matteo Berni, Marco Boi, Brunella Grigolo, Gianluca Giavaresi, Nicola Baldini, Valeria Cannillo,and et al. 2024. "A Multidisciplinary Evaluation of Three-Dimensional Polycaprolactone Bioactive Glass Scaffolds for Bone Tissue Engineering Purposes" Materials 17, no. 10: 2413.https://doi.org/10.3390/ma17102413
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.
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MDPI and ACS Style
Marchiori, G.; Bellucci, D.; Gambardella, A.; Petretta, M.; Berni, M.; Boi, M.; Grigolo, B.; Giavaresi, G.; Baldini, N.; Cannillo, V.;et al. A Multidisciplinary Evaluation of Three-Dimensional Polycaprolactone Bioactive Glass Scaffolds for Bone Tissue Engineering Purposes. Materials 2024, 17, 2413.https://doi.org/10.3390/ma17102413
AMA Style
Marchiori G, Bellucci D, Gambardella A, Petretta M, Berni M, Boi M, Grigolo B, Giavaresi G, Baldini N, Cannillo V,et al. A Multidisciplinary Evaluation of Three-Dimensional Polycaprolactone Bioactive Glass Scaffolds for Bone Tissue Engineering Purposes. Materials. 2024; 17(10):2413.https://doi.org/10.3390/ma17102413
Chicago/Turabian Style
Marchiori, Gregorio, Devis Bellucci, Alessandro Gambardella, Mauro Petretta, Matteo Berni, Marco Boi, Brunella Grigolo, Gianluca Giavaresi, Nicola Baldini, Valeria Cannillo,and et al. 2024. "A Multidisciplinary Evaluation of Three-Dimensional Polycaprolactone Bioactive Glass Scaffolds for Bone Tissue Engineering Purposes" Materials 17, no. 10: 2413.https://doi.org/10.3390/ma17102413
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.
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